Continuous bioprocessing
Integrating modular upstream and downstream operations for intensified and automated production.
RESEARCH THEME 01
Intelligent Bioprocess Engineering
Advancing integrated, continuous, autonomous and sustainable biomanufacturing.
Overview
At SIBES, Intelligent Bioprocess Engineering integrates biological systems, process intensification, microfluidics and computational intelligence.
Our goal is to connect upstream and downstream operations—including synthesis, enzymatic processing, filtration, chromatography and concentration—with monitoring and prediction technologies for efficient, reproducible and resource-conscious manufacturing.
Particular research interests include mRNA and saRNA manufacturing and transferable approaches for other biological products. Digital Twins and advanced AI-driven closed-loop manufacturing are emerging directions, not claimed as completed technologies.
Connected process architecture
This conceptual figure summarizes the SIBES Theme 1 workflow from nucleic acid synthesis and purification to PAT-enabled monitoring, chemometrics, machine learning, Digital Twin modelling and closed-loop process optimization.
The figure is used here as a research-theme overview and represents a conceptual, image-led summary of the theme.
Research focus areas
Microfluidics and process intensification
Microscale reactors, oscillatory flows, mixing, mass transfer and integrated separation.
Nucleic acid manufacturing
In vitro transcription, DNA removal, capture, concentration and future saRNA-related process development.
Process Analytical Technology (PAT)
Exploring in-line and at-line measurements of process variables and quality attributes.
Chemometrics and machine learning
Multivariate modelling, soft sensors, anomaly detection, quality prediction and optimization.
Hybrid Digital Twins
Mechanistic and data-driven simulation, state estimation, scenario testing and model-informed control.