S•SIBESSustainable and Intelligent Bioengineering Systems
PROJECTS & RESEARCH DIRECTIONS

From demonstrated platforms to emerging possibilities

Experimental achievements and new concepts are shown separately to preserve scientific accuracy.

Published experimental achievements

Integrated mRNA synthesis and purification
PUBLISHED · 2026

Integrated mRNA synthesis and purification

Demonstrated microfluidic IVT, enzymatic processing, separation, chromatography and concentration in an automated modular platform.

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Oscillatory microfluidic bioreactors
PUBLISHED · 2025

Oscillatory microfluidic bioreactors

Experimentally developed oscillatory-flow microreactors for intensified IVT and mRNA synthesis.

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Computer-vision-assisted separation
PUBLISHED · 2024

Computer-vision-assisted separation

Camera-based interface monitoring combined with feedback-controlled continuous microfluidic enzyme separation.

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Microfluidic downstream process engineering
PUBLISHED / COLLABORATIVE

Microfluidic downstream process engineering

Separation, flow dialysis, chromatography and modular purification research supporting integrated bioprocess systems.

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Emerging research directions

Current and proposed nucleic acid manufacturing research with in-line PAT, chemometrics, machine learning and Digital Twin control
Research vision (conceptual): data-enabled nucleic-acid manufacturing. Not a photograph of a fully implemented Digital Twin system.
Future directions across nucleic acid medicine modalities

Broader application landscape

Foundational reference figures can help frame future directions across nucleic-acid medicines without overstating experimental implementation.

The following are planned or exploratory directions. They are not claims of funded projects, completed systems or validated clinical products.

Foundational mRNA construct schematic for nucleic acid manufacturing
RESEARCH DIRECTION

AI-enabled nucleic acid manufacturing

Integrating continuous microfluidic mRNA/saRNA synthesis and purification with PAT, soft sensors, chemometrics and model-informed feedback.

Process analytical technology and instrumentation
RESEARCH DIRECTION

Hybrid Digital Twins for bioprocessing

Combining mechanistic models, experimental data and machine learning for state estimation, virtual experimentation and predictive optimization.

Smart microfluidic biochips
DESIGN EXPLORATION

Smart microfluidic biochips

Exploring CAD-guided device architectures, numerical simulation, fabrication routes, miniaturized analysis and sensing integration.

Prospective PhD research pathways in digital biomanufacturing
RESEARCH DIRECTION

PAT-driven autonomous purification

Coupling real-time sensing, multivariate analytics and flexible downstream unit operations for intelligent process control.

Exploring AI-informed nucleic acid biomanufacturing

01Biological inputsDNA templates and reagents
02Continuous synthesisMicrofluidic IVT and controlled reactions
03Downstream processingEnzymatic treatment, capture, TFF and polishing
04Quality measurementsPAT, concentration and purity data
05Intelligent layerChemometrics, ML, hybrid Digital Twin and predictive control

Conceptual research architecture. The individual elements are subject to experimental development and validation; the complete AI-controlled system is not represented as achieved.